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Exendin-4 enhances the binding of heat shock factor 1 to the promoter of heat shock protein (HSP) genes through SIRT1-mediated deacetylation, which then increased the expression of molecular chaperones HSP70 and HSP40 to alleviate lipid-induced hepatic ER stress

Now, here's where it gets interesting: semaglutide wasn't originally cooked up to help people squeeze into their skinny jeans

In recent months, Eli Lilly, the maker of Zepbound and Mounjaro, and Novo Nordisk, the maker of Ozempic and Wegovy, have each said they are able to meet the demand for the medications after facing shortages since 2022 due to the drugs' growing popularity

Visualization was performed at an accelerating voltage of 20 kV with the Hitachi S-4700 scanning electron microscope (Hitachi, Tokyo, Japan) in the Laboratory of Scanning Electron Microscopy and Microanalysis, Institute of Geological Sciences, Jagiellonian University, Krakow, Poland