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[33] In January 2023, Sinclair's lab published research in Cell purporting to support his Information Theory of Aging, the idea that mammalian aging is due to the loss of epigenetic information, and that Yamanaka factors could exert a degree of artificial control over senescence and rejuvenation in mice
Discuss with your clinician about adjusting your GLP-1 dosing schedule if constipation is severe Consider prescription medications for persistent constipation that doesnt respond to other measures When to seek medical advice Contact your healthcare provider if you experience: No bowel movement for more than 4-5 days Severe abdominal pain or distension Blood in the stool Constipation alternating with diarrhoea Unexplained weight loss or fatigue Constipation that doesnt improve with self-management strategies Long-term outlook For most patients, constipation either resolves as the body adjusts to GLP-1 therapy or can be effectively managed with dietary and lifestyle modifications
J Comp Neurol 1999;403:261-80.ArticlePubMed 107
In patients with volume depletion, correct this condition before initiating SYNJARDY or SYNJARDY XR
