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Recent advances have explored PEGylated lipid nanoparticles, which combine the benefits of stealth properties (to evade immune clearance) and controlled delivery

Lifestyle interventions remain the foundation of weight management: Dietary modification : A balanced, reduced-calorie diet rich in fruits, vegetables, whole grains, and lean proteins, potentially with support from a registered dietitian Physical activity : Following the UK Chief Medical Officers' guidelines of at least 150 minutes of moderate-intensity activity weekly, adapted to individual capabilities and any limitations from fibroid symptoms [15] Behavioural strategies : Including self-monitoring, goal-setting, and addressing emotional eating patterns, often facilitated through structured programmes or psychological support Alternative pharmacological options approved for weight management in the UK include: Orlistat : A lipase inhibitor that reduces fat absorption, available both on prescription and over-the-counter at lower doses, though gastrointestinal side effects can be troublesome Naltrexone/bupropion (Mysimba) : A combination therapy that affects appetite control centres in the brain, though it should be used with caution in certain conditions including hypertension Semaglutide (Wegovy) : A once-weekly GLP-1 receptor agonist with similar mechanism to Saxenda

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The characteristics of this subset are presented in Table 1