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As mentioned above, the link between TNF- and ROS adds another dimension of complexity to the TNF signaling network, as ROS act on numerous proteins required for the regulation of cellular homeostasis, including proteins that mediate cell proliferation, survival, death, differentiation, DNA repair and metabolism 30

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In several randomized clinical trials, a tomato-enriched diet could significantly decrease BP in overweight men/women [91], healthy male subjects who received fat meals [92], and people suffering from uncontrolled hypertension [15]