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However, no completed trial has examined the effect of GLP-1 RAs on cardiovascular events in patients with established CVD and overweight/obesity in the absence of type 2 diabetes

In animal models, preclinical work has also documented antinociceptive effects (attributed to indirect Met-enkephalin release [7]), antioxidant enzyme stimulation [11], and inhibition of hypothalamic somatostatin secretion [8]

The transcriptomic analysis indicated that the upregulation of Gsto2 in iSPNs affected redox homeostasis and created a hyperdopaminergic state similar to pre-symptomatic Huntingtons disease

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