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In clinical trials, semaglutide reduced daily calorie intake by about 24% versus placebo, with participants reporting less hunger, fewer food cravings, and better control of their eating

Another GLP-1 drug, Adlyxin, was discontinued by Sanofi in January 2023 amid rising competition from newer GLP-1 receptor agonists

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Reported Sex-Based Variability in the Literature Where sex-based data does appear, researchers generally attribute observed variability to differences in baseline endogenous IGF-1 and growth hormone signaling between male and female physiology, rather than to any fundamental difference in how IGF-1 LR3 binds or activates the IGF-1 receptor