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Toxic action of heavy metals seemed to induce the expression of genes encoding -glutamylcysteine (-ECS) and glutathione synthase (GSHS) enzymes by enhancing GSH levels
Retatrutide is also a 39 amino acid modified GIP molecule, but with changes to the amino acid structure to allow for activity at the GCGR site to achieve triple agonist activity at the GLP-1R, GIP-R, & GCGR
This is likely due to a combination of a single Sigma identified within the cytosol in relatively low abundance and the dominance of Mu class GST present
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