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37 Caution is advised in patients taking anticoagulants or antiplatelet therapies, although this is not a clear contraindication

Dysbiosis of gut microbiota in GBM based on randomisation studies Dysregulation of microorganisms, especially bacteria in the human body, leads to an imbalance in homeostasis, leading to immunosuppression and inflammation and modulating the therapeutic efficiency of drugs [167]

The dual mechanism enhances insulin secretion when glucose levels are elevated, suppresses glucagon release in a glucose-dependent manner, and slows gastric emptying, though this effect may attenuate over time with continued therapy

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