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Furthermore, this effect involves hypothalamic AMPK inhibition as pharmacological and genetic activation of AMPK ablates the effect of liraglutide on BAT thermogenesis

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10.1016/j.joms.2015.11.027 83 KhorolsurenZ.LangO.PallingerE.FoldesA.SzabolcsG

These reversible modifications are playing essential roles in gene regulation, X-inactivation, imprinting, and silencing of parasitic DNA elements ( PATHOLOGICAL ALTERATIONS OF GSTP1 METHYLATION PATTERNS DNA methylation, the addition of a methyl-group to cytosines is the most common epigenetic modification, inducing the reorganization of the gene locus and thus regulating gene expression (Smith and Meissner, 2013)