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no single prescriber monitors the total Common high-burden medications: diphenhydramine (many sleep aids/antihistamines), oxybutynin, some tricyclic antidepressants, promethazine Proton pump inhibitors (PPIs): documented depletion of B12 and magnesium nutrients critical to cognitive and metabolic health Statin-associated cognitive symptoms: documented in pharmacovigilance data and some RCTs mechanism likely involves CoQ10 and melatonin pathway interference Deprescribing the systematic, supervised reduction of polypharmacy is an emerging clinical discipline

This comprehensive evaluation is a critical step in identifying potential risks and tailoring the treatment plan to each individuals health profile

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