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Underlying health conditions like diabetes, renal impairment, and cardiovascular diseases can increase the likelihood of DILI, making comprehensive management of these conditions essential to minimize liver stress [94]

Heart failure with preserved ejection fraction now has reasonable evidence behind it the STEP-HFpEF programme with semaglutide and the SUMMIT trial with tirzepatide both showed clinical benefit. The number needed to treat over the 2.4-year mean follow-up of the meta-analysis was 66 to prevent one major cardiovascular event, 121 to prevent one death. Over time this number will likely fall further meaning fewer and fewer patients need to be treated to garner a benefit in the future

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