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Because both medications affect digestion and appetite regulation, gastrointestinal symptoms are the most commonly reported side effects

N Engl J Med 2015;373:211728

Insulin disrupts beta-adrenergic signaling to protein kinase A in adipocytes

Secondly, an 8-week follow-up duration may not be sufficient to observe long-term metabolic and clinical changes (e.g., the development of other medical co-morbidities)