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The current format has several clinical conditions visited multiple times (particularly obesity) and it might be worth considering how GSHR interactions with multiple other receptors may come into play in therapeutics. Response: We have reorganized the paper to discuss first the molecular mechanisms of all the dimers, followed by a separate discussion of possible ways to leverage these dimers to aid in therapeutics

158,159 The AUC of S- and R-warfarin was not affected by dulaglutide and tirzepatide administration

For example, caffeine and alcohol have been shown to reduce its effectiveness

12 Based on current cardiovascular outcome data such as that provided in SUSTAIN-6, the American Diabetes Association (ADA) now recommends GLP-1 receptor agonists with proven cardiovascular benefit as a preferred option for second-line add-on therapy in patients with T2DM and established atherosclerotic cardiovascular disease (ASCVD) following metformin and lifestyle-change intensification