does semaglutide cause hypoglycemia following the use of glucagon-like peptide-1 receptor agonists: a real-world analysis of post-marketing surveillance data Safety of Semaglutide - PMC

The key risks across both compounds include: Gastrointestinal adverse events (nausea, vomiting, diarrhoea), most pronounced during dose escalation Potential for gallbladder disease, consistent with rapid weight reduction Retatrutide-specific: dysesthesia and elevated resting heart rate [3] Both compounds: risk of hypoglycaemia when used in combination with insulin or sulphonylureas in diabetic models All compounds available through Sempica are strictly for research use by qualified professionals

Eijkelenboom and Burgering, 2013

H., Urva, S., et al

IGF-1 elevation is the primary mechanism through which full HGH increases the risk of insulin resistance, fluid retention, and certain growth-related effects at high doses