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2.3 Neonatal jaundice may reduce risk of PD development 2.3.1 Mechanisms underlying early development of DA neurons During mammalian embryonic development, Ventral Tegmental Area (VTA) DA neurons arise from the midbrain floor plate, where radial glial-like neural progenitors differentiate into three functionally distinct populations (Ono et al., 2007): the A8 retrorubral field, A9 substantia nigra pars compacta (SNc), and A10 ventral tegmental area (Toulouse and Sullivan, 2008)