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Representative bittering agents, bitter compounds and bitter enhancing compounds include, but are not limited to: acteoside, adhumulone, lupulone, aesculetin, esculin, L-alanyl-L-alanine, L-alanyl-L-isoleucyl-alanine L, L-valyl-L-valyl-amygdalin, picropodoside, amygdalin, isojaponin, antilupinene, antiisolupinene, arginine, L-arginyl leucine, arginyl proline, Asaronalyde, aspartyl aspartic acid, trihydroxy glucopyranoside, atropine, benzyl beta-d-arabinoside, benzyl beta-L-arabinoside, benzyl beta-d-fructoside, benzyl beta-d-galactoside, benzyl alpha-d-glucoside, Benzyl beta-D glucoside, benzyl alpha-D-mannoside, picric peptide derived from soy protein, butyl alpha-D glucoside, butyl beta-D glucoside, caffeine, Carnosifloside II, Carnosifloside III, Carnosifloside IV, catechin, epicatechin gallate, chaconine, alpha-chaconine, beta 2-chloramphenicol, cholic acid, chicory, humulone, colupulone, cryptochlorogenic acid, gamma-lactone, cucurbitacin B, cucurbitacin D, cyclalanine-glycine, cyclalanine-valine, cyclo (L-arginylglycyl-L-prolyl-L-phenylalanyl-L-isoleucyl-L-valyl), Cycloasparaginyl phenylalanine, cyclglycine-phenylalanine, cycloheximide cycloserine tryptophan, cyclopentyl (b) aza-8- (1H) -one, 7-methyl-2, 3,6, 7-tetrahydrocyclopentyl (b) azepin-8 (1H) -one, 2,3,6, 7-tetrahydro-7-hydroxy-7-methyl-cyclopent-2-en-1-one, 2, 5-dihydroxy-5-methyl-3- (1-piperidinyl) -cyclopent-2-en-1-one, 2, 5-dihydroxy-5-methyl-3- (1-pyrrolidinyl) cyclopent-2-en-1-one, pharmaceutically acceptable salts thereof, solvates thereof, and pharmaceutical compositions containing the same, 2, 3-di-1-pyrrolidinyl-cyclopent-2-en-1-one, 5-hydroxy-5-methyl-2, 3-di-1-piperidinyl-cyclopent-2-en-1-one, 5-hydroxy-5-methyl-2, 3-di-1-pyrrolidinyl-cyclopent-2-en-1-one, 5-methyl-2, 3-di-1-pyrrolidinyl-cyclopent-2-en-1-methylene-2, 3-di-1-pyrrolidinyl-cyclopent-2-en-1-one, 3-methyl-2- (1-pyrrolidinyl) -cyclophenylalanine-aspartic acid Amino acid, cycloproline-alanine, cycloproline-asparagine, cycloproline-glycine, cycloproline-isoleucine, cycloproline-leucine, cycloproline methionine, cycloproline-phenylalanine, cycloproline-proline, cycloproline-valine, cycloproline-phenylalanine, cynatranol, cynaropicrin, daidzein benzoate, bendinium ammonium saccharide, milo glycoside, dihydroxybenzoic acid, 2, 3-dihydroxybenzoic acid, 2, 4-ethyl b-L-arabinoside, ethyl alpha-D-glucoside, ethyl beta-D-glucoside, Eustomoside, gallic acid, gallocatechin gallate, Gaudidioside F, Gelidoside, Cynarcisinol, Cytosine, Genistein, gentiopicroside, gentisic acid, genomoside, Geshoidin, 6' -O-beta-D-glucosyl borneol glycoside, ucozaluzanin C, glutamyl aspartic acid, glutamyl glutamic acid, glycyl leucine, goitrogen, arundoin, damnacanthrin, brazilin, heptadeca-16-ene, 1-acetoxy-2, 4-dihydroxy-heptadeca-16-ene, 1,2, 4-trihydroxy-histidine, L-cumarone, humulone, lupulin, hydroxybenzoic acid, 4-Hymenoside A, Hymenoside B, Hymenoside C, Hymenoside D, Hymenoside E, Hymenoside F, isoflurone, cis-isoflurone, trans-isoleucine, L-isogenine, isogenistine, beta-isogenistein, genistein, 10, 17-dioxo-beta-isosbatin, 10-oxo-beta-galactoside, L-leucine, L-alanyl-L-leucine, N- [ (R2R) -6-amino-2- [ (4S) -2, 5-dioxo-4- (phenylmethyl) -1-imidazolidinyl ] -1-oxohexyl ] -L-alanyl-L-leucine, (4-1) -lactam, L-leucine, glycyl-L-alanyl-leucine, L-L-leucine, N- (N2-L-leucyl-L-leucine), L-leucyl-L-leucine, glycinamido) -L-leucine, N- (N-L-leucyl-L-a-glutamyl) -L-leucine, N- [ N2- [ N2- [ N- (1-L-leucyl-L-prolyl) -L-phenylalanyl ] -L-asparaginyl ] -L-glutaryl ] -L-leucine, N [ N2- [ N- [ N- (1-L-leucyl-L-prolyl) -L-phenylalanyl ] -L-seryl ] -L-glutaminyl ] -L-leucine, L-arginine, L, L-leucyl-L-valyl-leucine, phenylalanine, limonin monolactone, linarin, picroside (Lotaurarin), lupine, 13-hydroxy-lupine, 7-hydroxy-lupine, isradipine B, Lupoxes C, lupulone, Lupulione, Mellein (Mellein), 6-methoxy-methionine, L-methyl alpha-methionine, L-methyl-L-methionine, L-arabinoside, methyl beta-D-glucoside, methyl alpha-D-glucoside 2, 3-di-isoleucine, methyl alpha-D-glucoside 2, 3-di-leucine, Methyl -D-glucoside 2, 3-di-L-phenylalanine, methyl -D-glucoside 2, 3-di-threonine, methyl -D-glucoside 2, 3-di-tyrosine, methyl -D-mannoside, methyl -L-pyranoside, methyl -D-xyloside, naringin, neochlorogenic acid, -lactone, neohesperidin, Nuezhenide, Oleonezhenide, oleuropein, Olivieoside A, Olivieoside B, Olivieoside C, Perrotetin H, phenylalanine, L-phenyl -D-galactoside, D-glucoside, phenyl -D-glucoside, phenylthiourea, Phodomososide II, piperidine-2-carboxylic acid, 4- [ (2-carboxy-2-hydroxyethyl (thio) -piperidine carboxylic acid-2, 4- [ (2-carboxypropyl -D-fructoside, propyl -D-glucoside, propyl -D-glucoside, protocatechuic acid, prunetin, piceid, quinine, berberine-7-phthalate hydrochloride, ranitidine C, salicin, salidroside, holothuria scabra saponin, Scandenoside R5, sclareolide, scoposide, iridoid glycoside, seryl-lysyl-glycylleucine, choline sinapinate, solanine, -sparteine, 17-oxo-Stevisolide A, strychnine, Suavioside C1, suaviside D2, Suavioside F, sucrose octaacetate, sweroside, swertiamarin, Swertiamarinimarin, cyanogenic glycosides, TFI (furostane, -D-glucoside), theaflavin, acid ester A, galloyld, and other compounds, Gallate B, hydrolyzed tomatine, alpha-tricyclic dehydroisocuprulone, trilobatin, trihydroxybenzoic acid, 2,4, 6-tryptophan, L-uracil, 6-propyl-2-thio-L-valine, L-arginyl-L-prolyl-L-phenylalanyl-L-isoleucyl- (BPIa) valine, L-yohimbine, wild cucumber extract, denatonium benzoate and denatonium sugar

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It differs from native IGF-1 in that it possesses an arginine instead of a glutamic acid at the third position in its amino acid sequence, and also has an additional 13 amino acids at its N-terminus (MFPAMPLLSLFVN), for a total of 83 amino acids relative to the 70 of native IGF-1