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doi: 10.3389/ftox.2024.1515850 Received 23 October 2024 Accepted 31 December 2024 Published 20 January 2025 Volume 6 - 2024 Edited by Yong Ho Kim, United States Environmental Protection Agency (EPA), United States Reviewed by Colette Miller, United States Environmental Protection Agency (EPA), United States Meghan Rebuli, University of North Carolina at Chapel Hill, United States Updates Copyright 2025 Granata, Morosini, Valerii, Fagiolino, Sangiorgi, Ghini, Spisni, Vivarelli, Fairclough, Paolini and Canistro

Five-day dosing increases total weekly exposure by approximately 40%

Tsai, C

Similar challenges experienced in the field of oncology led to the implementation of innovative clinical trial designs, such as platform trials (see Box 4-1) and the use of master protocols to increase efficiency (Boxer and Sperling, 2023)