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Experiments were conducted under pressures analogous to the upper region of the sub-surface ocean of Europa [20 MPa to 30 MPa under an ice shell 20 to 30 km thick (Vance et al., 2007)]

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Additionally, explains, Vidmar, Topiramate provided minimal appetite suppression for her, which is consistent with what we sometimes see, its effects are modest, and individual response varies widely

This concern comes up regularly, and it is worth addressing directly