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Coverage for obesity medications is minimal across most provinces

Hayashi, N., Iida, T., et al

Semaglutide's stronger GLP-1 receptor binding drives more powerful appetite suppression and metabolic effects

In an experimental model of abdominal aortic aneurysm, topiramate markedly downregulated pro-inflammatory M1 macrophage activity, reduced the expression of TNF-, IL-1, and matrix metalloproteinase-9, and promoted a phenotypic shift of macrophages from M1 to M2, thereby mitigating pro-inflammatory activity and enhancing tissue repair processes (Attia et al., 2023)