Among the arsenal of antioxidants and detoxifying enzymes existing in mitochondria, mitochondrial glutathione (mGSH) emerges as the main line of defense for the maintenance of the appropriate mitochondrial redox environment to avoid or repair oxidative modifications leading to mitochondrial dysfunction and cell death
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Accordingly, GPx-1 is a crucial antioxidant enzyme involved in preventing the harmful accumulation of intracellular hydrogen peroxide