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At the endothelial level, they enhance nitric oxide (NO) availability, decrease NOX-derived oxidative stress, and reduce adhesion molecule expression, collectively improving vascular function

Blumentrath CG, Mller G, Teichmann D, Tiesmeier J, Petridou J (2019) Relapse of typhoid fever following delayed response to meropenem: A case report and review of previously published cases indicating limited clinical efficacy of meropenem for the treatment of typhoid fever

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and SLC22A12 , which encodes URAT1 ( Figure 1 - 4B )