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The role of the kynurenine pathway in cancer metabolism Tryptophan (TRP) is an essential amino acid required for protein synthesis as a precursor to serotonin and melatonin ( In cancer, IDO1 is overexpressed and has been linked to poor prognosis in several tumor types, including lung, ovarian, and pancreatic cancers ( Figure 1A )

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Primary antibodies against FOXO4 (Cell Signaling Technology 9472) and TP53BP1 (BD Biosciences 612523) were diluted in 1% BSA in PBST and incubated with the cells overnight at 4C