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doi: 10.1177/0269881110367732 183 LaprairieR

Patients should inform their prescribing physician about all supplements, including creatine, to ensure comprehensive monitoring and personalized recommendations

In published animal pharmacology it is administered in tiny amounts nanomole quantities into the brain ventricle, or micromole-per-kilogram amounts subcutaneously in rodents to study opioid analgesia [3] [5]