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Polymorphisms in IL-1 and in NOD-like receptor family pyrin domain containing 1 (NLRP1) inflammasome are associated with an increased risk of developing vitiligo

Treatment of cells with hydroxychloroquine or bafilomycin-A1, which increase the lysosomal pH and prevent iron(III) unloading from its endocytic carriers, led to reduced pools of chelatable cellular iron(III) and reactive lysosomal iron(II), as measured using specific fluorescent probes 27,28

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