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Although the final results are promising, no conclusions can be drawn due to the small sample size and doubts as to which of these symptoms are characteristic of endometriosis and which are a manifestation of Ni hypersensitivity [134]

Ceramides also activate apoptosis by depleting the anti-apoptotic proteins like Bcl-2 in neurons (Jazvinak Jembrek et al., 2015), inhibits the Akt/PKB survival pathway and activates the mitogen-activated protein kinases (MAPKs) (Iwayama and Ueda, 2013)

During therapy, the PSA doubling time (PSADT) markedly rose from the pre-treatment duration of 6.1 to 9.6 months while on treatment ( P = 0.044)