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Handling & Safety This material should be handled only by qualified personnel using appropriate laboratory practices

The proportion of adults who discontinued semaglutide was 18% at 3 months, 31% at 6 months, 42% at 9 months and 52% at 1 year

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( ad ) Mean (SE) change from baseline in fasting free fatty acids, n = 68 for AMG 133 and n = 6 for placebo at Day 1 (A), fasting triglycerides, n = 6 for AMG 133 and n = 6 for placebo at Day 1 (B), fasting total cholesterol, n = 68 for AMG 133 and n = 6 for placebo at Day 1 (C), fasting LDL, n = 6 for AMG 133 and n = 6 for placebo at Day 1 (D) after multiple ascending doses of AMG 133 or placebo