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Coverage for weight loss alone may be more limited or denied, depending on the plan

When used together, there may be an additive effect on heart rate , which could be clinically significant in patients with pre-existing cardiovascular conditions, including hypertension, arrhythmias, or coronary artery disease

These hepatic improvements, which may be associated with cotadutide's glucagon activity, indicate its potential as a therapeutic option for nonalcoholic steatohepatitis (NASH)