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Also, as patients with diabetes often switch between different drug classes, no information was provided as to the frequency of switching between semaglutide users and other antidiabetics or vice versa which might have led to exposure misclassification

In 2023, the EMA's Pharmacovigilance Risk Assessment Committee (PRAC) reviewed reports of thyroid cancer and pancreatitis associated with GLP-1 receptor agonists but concluded there was no causal link for thyroid cancer and did not recommend changes to prescribing guidance based on pancreatic cancer concerns