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When you start semaglutide or increase your dose, your gastrointestinal system experiences a sudden shift in how quickly food moves through your stomach, which can feel uncomfortable

This condition has a substantial impact on quality of life and can lead to overeating, thus increasing patients weight [4]

As a result, increased stiffness triggers the translocation of the transcription factor co-activators Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) to the nucleus where they interact with the transcriptional enhanced associate domain (TEAD) family of transcription factors to induce gene expression [85]