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More than a hundred attempts to develop transporter-utilizing (pro)drugs and nanoparticles/liposomes (hereinafter referred as nanocarriers) have been made to improve the uptake of CNS drugs into the brain

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and decreased the expression of caspase-3, inhibited apoptosis, and ultimately attenuated cisplatin-induced hair cell loss in the HEI-OC1 cell line ( Pomegranate extract (PE) is rich in polyphenols and exhibits strong antioxidant activity (Yazici et al., 2012)

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