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Patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 should not receive GLP-1 agonists

By the end of the second or third week, many patients begin to see noticeably smoother body lines and can usually resume moderate exercise, though full healing and final results may take several months

The FDA recommends using a non-oral contraceptive method or adding a backup method for 4 weeks after initiating tirzepatide and for 4 weeks after each dose increase

Injection site reactions (redness, itching, or discomfort) are usually mild and resolve spontaneously