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J Neurochem 74(5):22132216 Salvemini D, Misko TP, Masferrer JL, Seibert K, Currie MG, Needleman P (1993) Nitric oxide activates cyclooxygenase enzymes

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On a general level, in both Lurcher mice and human cerebellar patients, cerebellar dysfunction leads to behavioral and cognitive alterations (in humans defined as CCAS) and cerebellar motor syndrome (particularly cerebellar ataxia, which is well visible in both humans and cerebellar mutant mice, the mechanisms of which are relatively well understood)

Rather than binding directly to the enzyme active site, copper ions interfere with the enzymes function at concentrations achievable through topical or injectable application