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10.1172/jci94601 J Clin Invest

Combining Retatrutide with other GLP-1 or GIP agonists like Semaglutide or Tirzepatide is not recommended due to overlapping mechanisms and increased side effect risk

Some may feel a difference in energy or skin clarity within weeks, while for others, the benefits are more subtle and focused on long-term cellular protection

The efficacy of the new GLP-1 drugs was established in a series of clinical trials known as STEP (Semaglutide Treatment Effect in People with obesity)