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When weight loss exceeds 1.5 kg (approximately 3 pounds) per week, bile composition changes: cholesterol becomes supersaturated while bile salts and lecithin decrease, creating conditions favorable for stone formation

For compensated cirrhosis, cured HCV and ALD had similar LR and NLR mortality rates, while MASLD had higher NLR mortality

Key takeaways Semaglutide and testosterone replacement therapy (TRT) are generally considered safe to take together and may work well in combination, but only for men with clinically confirmed low testosterone

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