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Here is how to properly use Royal Blue Serum: Cleanse your skin (usually by showering) Add a LIGHT amount (roughly the size of your pinky finger tip), massage gently and inward to the area of application for 5-10 seconds Apply just enough cream to barely cover your face, neck and dcollet (for women, this is the neck, shoulders, back and upper chest) Its the same straightforward process as Sky Blue Cream, but with a few caveats: Unlike the cream, you MUST use a serum first before you apply anything else in your skin care routine Once the serum is applied, you MUST allow it to completely seep into your pores Next, apply a moisturizer to lock in the active ingredients found in the serum At 0.21 mL per pump and 2-4 pumps per standard application of the Royal Blue Serum, one bottle will last you roughly 30-60 days