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This induction is primarily mediated through the activation of the heme-regulated eIF2 kinase (HRI), which leads to increased ATF4 translation and the subsequent activation of genes involved in the stress response, highlighting UTXs role in modulating cellular stress pathways and its potential impact on cancer progression ( 3.1.1.3 CPEB1 Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1) is a post-transcriptional regulatory protein involved in mRNA translation

The complex duality of CHAC1 in oncology, acting as both a tumor suppressor by promoting ferroptosis and a potential oncogene in TP53 -mutant backgrounds, alongside its functions in neuroprotection and immunity, underscores its therapeutic potential

Ponton I, Marti Del Rio A, Gomez Gomez M, Sanchez-Garcia D (2020) Preparation and applications of organo-silica hybrid mesoporous silica nanoparticles for the co-delivery of drugs and nucleic acids