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Larger molecules like dulaglutide and albiglutide, which are fusion proteins with albumin or Fc domains, have molecular weights approaching or exceeding 60,000 Da, rendering them virtually impermeable to the BBB through classical routes

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Cell Death Differ (2026)

Under 15 psu, the MDHAR activity increased significantly on the 5 th day compared to 30 psu and they were largely promoted by adding BSO on the 1 st day and slightly induced by exogenous GSH on the 5 th day ( Figure 3E )