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In light of the significant heterogeneity detected by Cochranes Q test (Q = 131.3477, p = 0.00057), a random effects model was employed for the MR analysis
Likewise, restraint stress rapidly modulated KP enzyme expression in rats, with amygdala IDO increasing within 1 h, amygdala KMO and kynureninase rising by 4 h, hippocampal TDO decreasing within 4 h, hypothalamic TDO upregulated at 4 h, and medial prefrontal cortex kynureninase reduced shortly after stress with effects lasting at least 24 h [70]
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