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Aging cell, 2016;doi: Schafer, M
114 Ni II , like Zn II and Mn II , can perform Lewis acid chemistry, exemplified by two hydrolytic enzymes, the dinuclear Ni II enzyme urease (Section 5.1.2) and the mononuclear glyoxylase-I, but also functions as a cofactor in [NiFe]-hydrogenase and Ni-superoxide dismutase, among others, where both the Ni I and Ni III oxidation states must be accessible
IV administration gives the vitamin directly into the blood, which is critical in some situations
Corticotropin-releasing factor receptors and urocortins, links between the brain and the heart
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