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Symptoms Daytime sleepiness or fatigue Difficulty falling or staying asleep Waking up too early or feeling unrefreshed Impaired concentration, memory, and performance Mood changes: irritability, depression, or anxiety Unusual behaviors during sleep: snoring, gasping, limb movements, sleepwalking, or teeth grinding126 Diagnosis Clinical history: Detailed patient and, if possible, bed partner or family reports4

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Mol Cell Biochem 286:95101, PMID: 16583144 Halliwell B, Gutteridge JMC (1989) Free radicals in biology and medicine