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A waist circumference over about 35 inches in women and 40 inches in men is linked to increased risk, regardless of overall body weight

For patients approaching metabolic optimization from a longevity rather than disease-treatment frame, the full context of metabolic health matters: fasting glucose, insulin sensitivity assessed through fasting insulin or HOMA-IR, visceral adiposity assessed through imaging or waist circumference, liver enzyme trends, and lipid fractionation

This dual mechanism often results in improved appetite suppression and metabolic benefits