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"Activation of the central melanocortin system chronically reduces body mass without the necessity of long-term caloric restriction." American Journal of Physiology-Endocrinology and Metabolism

54 The phase 3 randomised controlled Study of Retratrutide in Participants with Obesity and Cardiovascular Disease (TRIUMPH-3) seeks to determine the percentage change from baseline in body weight in patients with BMI 35 kg/m 2 and established CVD (clinical trial number NCT05882045