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GLP-1 medications are beginning to influence consumer habits

Some users adopt a 3-month on, 1-month off strategy to prevent desensitization and maintain receptor sensitivity

Pickart estimated lethal dose at approximately 22,500 mg for humans (300-fold above effective doses), with animal LD50 studies in mice showing 8 mg per 25g mouse (320 mg/kg, translating to ~22,400 mg for 154 lb human)

Table 1) Sleep abnormalities Individuals with PWS have sleep-disordered breathing, including central and obstructive sleep apnea, abnormal arousal, abnormal circadian rhythm in REM sleep, reduced REM latency, and abnormal response to hypercapnia 26, 27 as well as excessive daytime sleepiness