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Recently, a human gene mutation of PAPP-A2, a circulating and tissue protease with IGFBP-5 (and to some extent IGFBP-3) as its primary substrate (Gaudamauskes et al), was demonstrated to have a marked growth phenotype involving fetal and post-natal growth retardation in children in a consanguineous family (43)
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It is highly stable in acidic environments, remaining intact for more than 24 hours, which allows it to be administered orally without the need for protective carriers
Without enough Vitamin B12, they cant make DNA well
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