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For instance, the pleckstrin homology domain interacting protein (PHIP) protein acts as a transcriptional co-regulator that directly modulates POMC transcription, whereas the SIM1 transcription factor is indispensable for the normal development of the PVN and the proper expression of MC4R [8,13]

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[2] [3] NAD+ is continuously recycled within cells as it transitions between its many forms through salvage mechanisms

This reduction can lead to various skin concerns, including dryness, dullness, and premature aging