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Dietary polyphenol quercetin targets pancreatic cancer stem cells

While cholesterol reduction was not the primary endpoint, the overall cardiovascular benefit reflects improvements in multiple risk factors, including lipid panels, blood pressure, and inflammation markers

To determine whether the colistin-induced depolarization was the result of the opening of the mitochondrial permeability transition pore (mPTP), mitochondria were co-incubated with colistin and cyclosporin A, a well-characterized desensitizer of the mPTP 31,32

The study included 17,604 adults over the age of 45 from across 41 countries, each with a BMI of more than 27 and established cardiovascular disease, with no history of diabetes