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While both target metabolic disease, tirzepatide is a GIP/GLP1 dual agonist injectable, whereas orforglipron is a selective, oral GLP1 receptor agonist
a few might be required to take a break or change their schedule
Patients whose primary goal is maximum weight loss and who want the drug with the strongest efficacy data Those who have plateaued on semaglutide and need a more potent treatment Adults with obesity and obstructive sleep apnea (the only FDA-approved pharmacotherapy for OSA) Type 2 diabetes patients who need stronger HbA1c reduction beyond what semaglutide can provide Patients for whom insurance covers tirzepatide at comparable or lower cost to semaglutide Who should choose semaglutide
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