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There are uneven shape irregular edges variance in color or discoloration larger than the size of a pencil erases change in size, contour, or coloration itching or seeping a sore that doesnt heal coloring that spreads from the spot to the surrounding skin redness of swelling that spreads to the surrounding skin pain, tenderness, or itchiness texture change in the mole such as scaliness, oozing, bleeding, or the appearance of a lump

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Oxidative Stress, Dysfunctional Glucose Metabolism and Alzheimer Disease. Nature Reviews Neuroscience 20: 148160

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