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When to Seek Medical Help for Pain, Numbness, or Severe GI Symptoms Watch for red flags: Sudden severe abdominal pain Persistent vomiting Blood in stool Marked muscle weakness Dark urine New numbness and tingling Those signs may indicate complications like: Severe dehydration Electrolyte crises Rare muscular injury Talk to your prescriber before changing doses

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275,278 In addition, AMPK can promote SIRT1 activity via NAMPT activation