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As an indispensable member of anti-tumor immunity, CD4 + T cells promote anti-tumor immunity by assisting CD8 effector T cells or directly eliminate tumor cells by acting as cytotoxic T cells ( Notably, we also found a negatively correlation between GLP-1 signaling score and TMB/MSI in LIHC, LUAD, BLCA, HNSC, STAD, BLCA, COAD and so on, demonstrating there may be high microsatellite instability or tumor mutation burden in these tumors, thus antitumor immunity is more likely to be activated

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